University of Texas Medical Branch

Edward I. Bradbridge Thompson, M.D. Papers

Descriptive Summary

Creator: Thompson, Edward
Title: Edward I. Bradbridge Thompson, M.D. Papers
Dates: (1920-1978)
Identification: MS 92
Extent: 3 Records Center Boxes and 1 Oversize Box, 52.5 Inches
Language: Materials are written in English
Repository: University of Texas Medical Branch at Galveston, Texas. Moody Medical Library, Truman G. Blocker, Jr. History of Medicine Collections, Galveston, TX 77555-1035. Phone: 409.772.2397.

Biographical Note

Edward I. Bradbridge Thompson, M.D. (1933 - ) served as I.H. Kempner Professor of Human Genetics Biochemistry and Molecular Biology at the University of Texas Medical Branch (UTMB). He earned his BA from Rice University in 1955 and his MD from Harvard Medical School in 1960. In 1984, Dr. Thompson began his career at UTMB as the Chairman of the Department of Human Biological Chemistry and Genetics (now the Department of Biochemistry and Molecular Biology) a position that he held until 2003. He was also instrumental in the creation of the Molecular Biology Center at UTMB. This department performs extensive research in the cellular and molecular actions of steroids, especially glucocorticoids and oxysteroids. Throughout his career, Dr. Thompson published extensively and also served as the founding editor, and the first editor-in-chief, of the journal Molecular Endocrinology. His areas of research included; steroids, oncogenes, gene regulation, and molecular biology of gene expression.

Scope and Content

The Edward I. Bradbridge Thompson, M.D. Papers consist of three records center boxes. The collection is divided into eight series: Biographical Information, Class Notes, Teaching Files, Conferences, Drafts and Manuscripts, Publications, Human Biological Chemistry and Genetics Department Files, and Miscellaneous. Reprints of Dr. Thompson’s published articles are also included.

*One oversize box contains a poster advertising the creation of Molecular Endocrinology, cassette tapes, and several discs: cds, 5” floppy discs, and a zip disc. For preservation reasons, the collection has been re-foldered and re-boxed using acid free materials. Original item order has been preserved whenever possible.


Arrangement of Collection

The collection is organized in 3 record center boxes and 1 oversize box. This collection is divided into 8 series as follows:
Biographical Information
Class Notes
Teaching Files
Drafts and Manuscripts
Human Biological Chemistry & Genetics Department Files
OVS Box contains Poster, Cassette Tapes, CDs, Floppy Disks, Zip Disk


Access Restrictions

The collection is open for research use. Materials may be viewed in the Truman G. Blocker, Jr. History of Medicine Collections of the Moody Medical Library, located on the 3rd floor.


Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch


American Cancer Society
Gene Expression
Gene Regulation
Human Biological Chemistry
Human Genetics
Medical Research
Microbiology and Immunology Science
Molecular Biology
University of Texas Medical Branch

Administrative Information

Preferred Citation

[Identification of Item], in the Edward I. Bradbridge Thompson, M.D. Papers, MS 92, Truman G. Blocker, Jr. History of Medicine Collections, Moody Medical Library, University of Texas Medical Branch at Galveston, Texas.

Processing Information

These records were organized and processed by staff of the Truman G. Blocker, Jr. History of Medicine Collections. Finding aid prepared by Robert Marlin and Kelly Caldwell; encoded by Lisa A. Reyna in EAD, version 2002 in June of 2014.

Detailed Description of Collection


BOX 1 FOLDERS 1-3/Edward I. Bradbridge Thompson, M.D. Papers (MS 92)/Series 1: Biographical Information
This series includes Dr. Thompson’s curriculum vitae; correspondence; and a transcription of an interview with Dr. Thompson about his management of the Department of Human Biological Chemistry and Genetics.

Box Folder
1 1 Curriculum Vitae
2 Interview with Dr. Brad Thompson and Margie Wronski by Laura Jones, September 25, 2007
3 Correspondence


BOX 1 FOLDERS 4-10/Edward I. Bradbridge Thompson, M.D. Papers (MS 92)/Series 2: Class Notes
This series includes handwritten notes taken in Dr. Thompson’s classes at Harvard Medical School; notes concerning experiments conducted and cloning, in addition to a lab book.

Box Folder
1 4 Class Notes
5 Physiology II, March 1956-May 1956
6 Experiments, 1965-1966 (1 of 2)
7 Experiments, 1965-1966 (2 of 2)
8 Experiments that established "HTC" cells Thompson, Tomkins, and Curran 1966
9 Clones, 1965-1972
10 Lab Book, 1968


BOX 1 FOLDERS 11-12/Edward I. Bradbridge Thompson, M.D. Papers (MS 92)/Series 3: Teaching Files
This series includes worksheets from receptor purification and protein assay trials; and a printout of a powerpoint presentation on genes.

Box Folder
1 11 Receptor purification and protein assay trials, 1985
12 Powerpoint, March 18, 2011


BOX 1 FOLDER 20-BOX 2 FOLDER 3/Edward I. Bradbridge Thompson, M.D. Papers (MS 92)/Series 4: Conferences
This series includes materials from various conferences and symposia including; Hormone Action Gordon Research Conference; Nobel Symposium; Keystone Symposia; International Congress on Hormonal Steroids and Hormones and Cancer; Structural Biology Symposium; and Sealy Center for Molecular Science and Department of Microbiology and Immunology Science Forum. The folders are organized in chronological order.

Box Folder
1 13 Hormone Action Gordon Research Conference Meriden, NH (August 9-13, 1971)
14 Hormone Action Gordon Research Conference Meriden, NH (August 8-12, 1983)
15 Nobel Symposium 57 Steriod Hormone Receptors: Structure and Function Sweden (September 5-10, 1983) 1 of 2
16 Nobel Symposium 57 Steriod Hormone Receptors: Structure and Function Sweden (September 5-10, 1983) 2 of 2
17 Hormone Action Gordon Research Conference Meriden, NH (August 2-6, 1993)
18 Keystone Symposia on Molecular and Cellular Biology Tamarron, CO (February 18-23, 1997)
19 Hormone Action Gordon Research Conference Meriden, NH (July 25-30, 1999)
20 Keystone Symposia Nuclear Receptor Superfamily Snowbird, UT (April 13-19, 2002)
Box Folder
2 1 International Congress on Hormonal Steroids and Hormones and Cancer Fukuoka, Japan (October 21-25, 2002)
2 Eighth Structural Biology Symposium Galveston, TX (May 2-4, 2003)
3 Sealy Center for Molecular Science and Department of Microbiology and Immunology Science Forum Galveston, TX (May 30, 2003)


BOX 2 FOLDERS 4-8/Edward I. Bradbridge Thompson, M.D. Papers (MS 92)/Series 5: Drafts and Manuscripts
This series includes consensus group, trip to National Institutes of Health, historical paper drafts; and a manuscript titled Characterization of a human lymphoblast glucocorticoid receptor by means of affinity labeling and anti-receptor antiserum.

Box Folder
2 4 Draft: Consensus Group (September 7, 1983)
5 Draft: Trip to National Institutes of Health (NIH) (April 5, 1997)
6 Draft: "historical" paper by E. Brad Thompson, Laura Jones, and Hannah Landecker
7 Manuscript: Characterization of a human lymphoblast glucocorticoid receptor by means of affinity labeling and anti-receptor antiserum (1 of 2)
8 Manuscript: Characterization of a human lymphoblast glucocorticoid receptor by means of affinity labeling and anti-receptor antiserum (2 of 2)


BOX 2 FOLDER 143-BOX 3 FOLDER 149/Edward I. Bradbridge Thompson, M.D. Papers (MS 92)/Series 6: Publications
This series includes 280 reprints of published articles in addition to a few UTMB publications. The reprints were left in their original order as received from the author.

Box Folder
2 9 Isolation of an Encephalitogenic Phospholipid-Protein Complex by Dialysis of Myelin in Organic Solvents
10 Current Studies on the Lipids and Proteins of Myelin
11 The Relationship of Myelin Proteins to Experimental Allergic Encephalomyelitis
12 Induction of Tyrosine Ketoglutarate Transaminase by Steroid Hormones in a Newly Established Tissue Culture Cell Line
13 Tyrosine Transaminase Induction in Mammalian Cells in Tissue Culture
14 Hormonal Control of Protein Synthesis at the Translational Level
15 Stimulation of Tyrosine Aminotransferase Synthesis by Dexamethasone Phosphate in Cell Culture
16 Exploitable Molecular Mechanisms and Neoplasia
17 Control of Specific Gene Expression in Higher Organisms
18 Glucuronyltransferase Activity in Transplantable Rat Hepatomas
19 Dexamethasone Phosphate-Induced Synthesis of Tyrosine Aminotransferase in Hepatoma Tissue Culture Cells
20 The Biochemistry of the Lipids and Proteins of White Matter
21 Superinduction of Tyrosine Aminotransferase Actinomycin D in Rat Hepatoma (HTC) Cells
22 Steroid Control of Tyrosine Aminotransferase in Hepatoma Tissue Culture (HTC) Cells
23 A Histochemical Method for the Demonstration of Tryosine Aminotransferase in Tissue Culture Cells, and Studies of this Enzyme in Hepatoma Tissue Culture Cells
24 Partial Purification by Affinity Chromatography of Tyrosine Aminotransferase-Synthesizing Ribosomes from Hepatoma Tissue Culture Cells
25 Expression of Tyrosine Aminotransferase Activity in Somatic-Cell Heterokaryons: Evidence for Negative Control of Enzyme Expression
26 Tyrosine Aminotransferase Induction Regulation Variant in Tissue Culture
27 Radioactive Assay for Tyrosine Aminotransferase
28 Expression of Aryl Hydrocarbon Hydroxylase Induction and Suppression of Tyrosine Aminotransferase Induction in Somatic-Cell Hybrids
29 Variation in Tyrosine Aminotransferase Induction in HTC Cell Clones
30 Purification of Tyrosine Aminotransferase by Affinity Chromatography
31 Polydeoxythymidylate Inhibition of Rabbit Retculocyte RNA Dependent Protein Synthesis in a Krebs II Ascites Cell System
32 Glucocorticoid Binding Proteins in Human Leukaemic Lymphoblasts
33 Inhibition of Cell-Free Globin Synthesis by Polydeoxythymidylate
34 Contact Inhibition and Gene Expression HTC/L Cell Hybrid Lines
35 Temporal Aspects of Macromolecular Synthesis in Eukaryotic Cells
36 Drug Combinations in Malignant Diseases
37 Glucocorticoid-Binding Proteins in Human Acute Lymphoblastic Leukemic Blast Cells
38 Differences Between Cytoplasmic Glucocorticoid-Binding Proteins Shown by Heterogeneity of Nuclear Acceptor Sites
39 Transfer Ribonucleic Acid in Hepatoma Tissue Culture Cells. I. Induction in Vivoby Dexamethasone Phosphate of Phenylalanine-Accepting Activity
40 Transfer Ribonucleic Acid in Hepatoma Tissue Culture Cells. II. Dexamethasone Phosphate Induction of tRNAphe Analyzed under Cell-Free Conditions
41 Progress in Endocrinology and Metabolism
42 Aryl Hydrocarbon Hydroxylase and Tyrosine Aminotransferase Activities in Somatic-Cell Hybrids Derived from Hepatoma Tissue Culture HTC (rat) Cell and 3T3 (mouse) Benzo[a]pyrene-Resistant Cells
43 Steroid Receptors and the Mechanism of the Specificity of Glucocorticoid Responsiveness of Somatic Cell Hybrids between Hepatoma Tissue Culture Cells and Mouse Fibroblasts
44 Gene Expression in Animal Cells
45 Enzyme Expression and Growth Control in HTC Cells and Hybrids of HTC Cells with other Cell Types
46 Cytoplasmic Glucocorticoid-Binding Proteins in Glucocorticoid-Unresponsive Human and Mouse Leukemic Cell Lines
47 The Role of Transcortin in Glucocorticoid Mediated Enzyme Induction: Tyrosine Aminotransferase Induction in Hepatoma Tissue Culture Cells
48 Control of Enzyme Induction and Growth in Tumor Cells and Cell Hybrids
49 Pyridoxamine Phosphate
50 Glucocorticoid Receptors
51 Enrichment of Polysomes Synthesizing a Specific Protein by use of Afinity Chromatography
52 Expression of Liver-Specific and other Differentiated Functions in Hybrids between Cultured Hepatoma Cells and L Cells
53 Glucocorticoid Binding Proteins in Myeloblasts of Acute Myleogenous Leukemia
54 Serum-Free Growth of HTC Cells Containing Glucocorticoid-and Insulin-Inducible Tyrosine Aminotransferase and Cytoplasmic Glucocorticoid Receptors
55 Interaction of Spironolactone and Digitalis with the 5α-Dihydrotestosteron (DHT) Receptor of Rat Ventral Prostate
56 A Method for Enucleating Cultured Mammalian Cells
57 Steroid-Binding Proteins in Carcinoma of the Human Male Breast
58 Rescue of a Rat Tropic Rat Hepatoma Virus Pseudotype Kirsten Sarcoma Virus by Co-Cultivation of Hepatoma Tissue Culture Cells with K-NRK Cells
59 Characteristics of Cell Membranes from Somatic Cell Hybrids between Rat Hepatoma and Mouse L-Cells
60 The Cellular Actions of Glucocorticoids in Relation to Human Neoplasms
61 Delayed Malignancy and Altered Growth Properties of Somatic Cell Hybrids between Rat Hepatoma and Mouse L-Cells
62 Variants of HTC Cells with Low Tyrosine Aminotransferinase Inducibility and Apparently Normal Glucocorticoid Receptors
63 Effect of Concanavalin A on Tyrosine Aminotransferase in Rat hepatoma Tissue Culture Cells
64 Extinction of Hemoglobin Inducibility in Friend Erythroleukemia Cells by Fusion with Cytoplasm of Enucleated Mouse Neuroblastoma or Fibroblast Cells
65 Interaction of Glucocorticoid Hormones and Cyclic Nucleotides in Induction of Tyrosine Aminotransferase in Cultured Hepatoma Cells
66 Characterization of 2 Forms of Glucocorticoid Hormone-Receptor Complex Separated by Deae-Cellulose Column Chromatography
67 Steroid Hormone Actions in Tissue Culture Cells and Cell Hybrids-Their Relation to Human Malignancies
68 The Stability of Tyrosine Aminotransferase and other Proteins in Enucleated Rat Hepatoma Tissue Culture Cells
69 Characterization of a Glucocorticoid-Sensitive Human Lymphoid Cell Line
70 Ontogeny and Biochemical Properties of Glucocorticoid Receptors in Mid-Gestation Mouse Embryos
71 Isolation and Characteristics of L-Cell Variants with Altered Sensitivity to Glucocorticoids
72 Glucocorticoid Receptor Function in Leukemic Cells
73 The Relation between Estrogen Receptors and Response Rate to Cytotoxic Chemotherapy in Metastatic Breast Cancer
74 Use of a Human Lymphoid Cell Line to Evaluate Interactions between Prednisolone and other Chemotherapeutic Agents
75 An Association between Steroid Hormone Receptors and Response to Cytotoxic Chemotherapy in Patients with Metastatic Breast Cancer
76 Association between Steroid Hormone Receptors and Response Rate to Cytotoxic Chemotherapy in Metastatic Breast Cancer
77 Distribution, Frequency and Quantitative Analysis of Estrogen, Progesterine, Androgen and Glucocorticoid Receptors in Human Breast Cancer
78 Dexamethasone Induces Irreversible G1 Arrest and Death of a Human Lymphoid Cell Line
79 Anti-Inflammatory Pyrazolo-Steroids: Potent Glucocorticoids Containing Bulky A-Ring and No C3-Carbonyl
80 Report on the International Union Against Cancer workshop on Steroid Receptors in Leukemia
81 CEM Cells: A Model System for Studies of Glucocorticoid Action in Human Lymphoblastic Leukaemia
82 Liver Cells (HTC)
83 Glucocorticoids and Lysosomes
84 Glucocorticoids Induction of Tyrosine Aminotransferase in Cultured Cells
85 Glucocorticoids and Lysosomes
86 Unlinked Control of Multiple Glucocorticoid-Sensitive Processes in Spontaneous HTC Cell Variants
87 Association between Steroid Hormone Receptor Status and Disease-Free Interval in Breast Cancer
89 Unlinked Control of Multiple Glucocorticoid-Induced Processes in HTC Cells
90 Relationship between the Progesterone, androgen, and Glucocorticoid-Receptor and Response Rate to Endocrine Therapy in Metastatic Breast Cancer
91 Fluorescent Chemoaffinity Labeling. Potential Application of New Affinity Labeling Technique to Glucocorticoid Receptors
92 The Influence of Steroid Hormone Receptors on Response to the Chemotherapy in Patients with Metastatic Breast Cancer
93 Clinical Correlations of Glucocorticoid Receptors in Human Acute Lymphoblastic Leukemia
94 Human Leukemic Cells in Culture - A Model System for the Study of Glucocorticoid-Induced Lymphocytolysis
95 Pitfalls in the Interpretation of Steroid Receptor Assays in Clinical Medicine
96 Glucocorticoid Receptors and Glutamin Synthetase in Leukemic Sézary Cells
97 Hormonal Control of Tyrosine Aminotransferase, Prolactin, and Growth Hormone Induction in Somatic Cell Hybrids
98 Glucocorticoid Sensitivity and Receptors in BALB/c T Cell Lymphoma Lines Expressing Restricted Patterns of Ly Differentiation Antigens
99 Synthesis and Biological Activity of Some Novel, Chemically Reactive Glucocorticoids
100 Clinical Correlations of Steroid Receptors and Male Breast Cancer
101 Regulation of Hepatoma Tissue Culture Cell Yyrosine Aminotransferase Messenger Ribonucleic Acid by Dexamethasone
102 Activation-Labile' Glucocorticoid-Receptor Complexes of a Steroid-Resistant Variant of CEM-C7 Human Lymphoid Cells
103 Genomic Organization of Rat Prolactin and Growth Hormone Genes
104 Estrogen Receptor Status: An Important Variable in Predicting Response to Endocrine Therapy in Metastatic Breast Cancer
105 Multiple Actions of Glucocorticoids Studied in Cell Culture Systems
106 Unique Long-Acting Antiglucocorticoid in Whole and Broken Cell Systems
107 Glucocorticoid Actions in a Human Acute Lymphoblastic Leukemia, T-Cell Line: A Model System for Understanding Steroid Therapy
108 Cytosolic Proteins that Bind Oxygenated Sterols: Cellular Distribution, Specificity and Some Properties
109 Deacylcortivazol Acts through Glucocorticoid Receptors
110 Isolation and Characterization of Dexamethasone-Resistant Mutants from Human Lymphoid Cell Line CEM-C7
111 Dexamethasone 21-Mesylate: An Affinity Label of Glucocorticoid Receptors from Rat Hepatoma Tissue Culture Cells
112 Factors Affecting Adrenocortical Hormone Function
113 The Use of Human Cell Cultures as Model Systems for Studying the Action of Glucocorticoids in Human Lymphoblastic Leukaemias
114 Regulation of Hormonally Controlled mRNA Synthesis and Gene Expression in Variant Somatic Cells and Cell Hybrids
115 Non-Glucocorticoid Receptor-Mediated Effects on the Potent Glucocorticoid Deacylcortivazol
116 Glutamine Synthetase Induction by Glucocorticoids in the Glucocorticoid-Sensitive Human Leukemic Cell Line CEM-C7
117 Affinity Labeling of Glucocorticoid Receptors: New Methods in Affinity Labeling
118 Defective Steroid Receptors in the Glucocorticoid Resistant Clone of a Human Leukemic Cell Line
119 Deacylcortivazol, A Potent Glucocorticoid with Unusual Structure and Unusual Anti-Leukemic Cell Activity
120 Somatic Cell Hybridization of Growth Hormone-Producing Rat Pituitary Cells and Mouse Fibroblasts Results in Extinction of Growth Hormone Expression via a Defect in Growth Hormone RNA Production
121 An Improved Method for Preparing Large Arrays of Bacterial Colonies Containing Plasmids for Hybridization: in Situ Purification and Stable Binding of DNA on Paper Filters
122 A Novel Synthetic Glucocorticoid, with Therapeutic Potential in Acute Lymphoblastic Leukemia
123 Dissociation of Steroid Binding to Receptors and Steroid Induction of Biological Activity in a Glucocorticoid-Responsive Cell
124 Mechanism of Extinction of Growth Hormone and Prolactin Genes in Somatic Cell Hybrids
125 Corticosteroid Effects on an Acute Lymphoblastic Leukemic Cell Line: A Model for Understanding Steroid Therapy
126 Glucocorticoid-Resistant Human Acute Lymphoblastic Leukemic Cell Line with Functional Receptor
127 Laboratory Methods Sequential Comparative Hybridizations Analyzed by Computerized Image Processing Can Identify and Quantitate Regulated RNAs
128 Rat Growth Hormone Gene Regulation Studied by Gene Transfer into Hybrid Cells
129 Properties and Function of Human Glucocorticoid Receptors in Steroid-Sensitive and -Resistant Leukemic Cells
130 Receptores de Glucocorticoides en Células de Leucemia Linfoblástica Aguda
131 Rat Growth Hormone Expression in Cell Hybrids
132 Glucocorticoid Versus Antiglucocorticoid Activity: Can a Single Functional Group Modification of Glucocorticoid Steroids Always Convey Antiglucocorticoid Activity?
133 Identification of Human Leukemic Glucocorticoid Receptors Using Affinity Labeling and Anti-Human Glucocorticoid Receptor Antibodies
134 Molybdate-Sensitive and Molybdate-Resistant Activation-Labile Glucocorticoid-Receptor Mutants of the Human Lymphoid Cell Line CEM-C7
135 Methylation of Either Cytosine in the Recognition Sequence CGCG Inhibits ThaI Cleavage of DNA
136 The Karyotype of the Glucocorticoid-Sensitive, Lymphoblastic Human T-Cell Line CCRF-CEM Shows a Unique Deleted and Inverted Chromosome 9
137 Glucocorticoid Receptors in Human Leukemias and Related Diseases
138 Analysis of Glucocorticoid-Resistant Human Leukemic Cells by Somatic Cell Hybridization
139 Identification of Human Glucocorticoid Receptor cDNA Clones by Epitope Selection
140 Monoclonal Antibody to the Rat Glucocorticoid Receptor
141 Formation of a Fluorescent Glucocorticoid Receptor-Steroid Complex in HTC Cell Cytosol
142 [3H]Cortivazol: A Unique High Affinity Ligand for the Glucocorticoid Receptor
143 Primary Structure and Expression of a Functional Glucocorticoid Receptor cDNA
Box Folder
3 1 Mechanism of Steroid Hormone Action
2 The Role of Receptors in Biology and Medicine
3 Mechanisms of Glucocorticoid Resistance in Leukemic Cells
4 Glucocorticoid Receptors and Glucocorticoid Resistance in Human Leukemia in Vivo and in Vitro
5 Rat Growth Hormone Gene Expression is Correlated with an Unmethylated CGCG Sequence Near the Transcription Initiation Site
6 Monoclonal Antibodies to Human Leukemic Glucocorticoid Receptor
7 Glucocorticoid Hormone Receptors
8 Molecular Endocrinology
9 Resistance to Endocrine Therapy a Panel Discussion
10 Establishment and Characterization of Human Myeloid Cell Line from Philadelphia Chromosome-Negative Myeloblastic Leukemia Arising in a Patient with Myelodysplastic Syndrome
11 The Structure of the Human Glucocorticoid Receptor and its Gene
12 Complementation between Glucocorticoid Receptor and Lymphocytolysis in Somatic Cell Hybrids of Two Glucocorticoid-Resistant Human Leukemic Clonal Cell Lines
13 Molecular Genetic Analysis of Glucocorticoid Actions in Human Leukemic Cells
14 Mechanisms of Glucocorticoid Function in Human Leukemic Cells: Analysis of Receptor Gene Mutants of the Activation-Labile Type Using the Covalent Affinity Ligand Dexamethasone Mesylate
15 Unlinked Regulation of the Sensitivity of Primary Glucocorticoid-Inducible Responses in Mouse Mammary Tumor Virus Infected Fu5-5 Rat Hepatoma Cells
16 Extinction of Growth Hormone Expression in Somatic Cell Hybrids Involves Repression of the Specific Trans-Activator GHF-1
17 Glucocorticoid Resistance in Leukemic Cells
18 Steroid Hormone Action, Vol. 75, UCLA Symposia on Molecular and Cellular Biology
19 Abnormal Glucocorticoid Receptor Gene and mRNA in Primary Cortisol Resistance
20 Flow Cytometric Analysis of Glucocorticoid Receptor Using Monoclonal Antibody and Fluoresceinated Ligand Probes
21 Demonstration of the Intracellular Localization and Up-Regulation of Glucocorticoid Receptor by the Situ Hybridization and Immunocytochemistry
22 Differential Modulation of Gene Induction by Glucocorticoids and Antiglucocorticoids in Rat Hepatoma Tissue Culture Cells
23 Interactions of the Phenylpyrazolo Steroid Cortivazol with Glucocorticoid Receptors in Steroid-Sensitive and -Resistant Human Leukemic Cells
24 Glucocorticoid Receptor Expression in Receptorless Mutants Isolated from the Human Leukemic Cell Line CEM-C7
25 Growth Inhibition of CEM Cells by Glucocorticoids: C-MYC Down Regulation and the Topology of the Glucocorticoid Receptor
26 Glucocorticoid Effect on Oncogene/Growth Gene Expression in Human T Lymphoblastic Leukemic Cell Line CCRF-CEM
27 Differential Regulation of Tyrosine Amino-Transferase by Glucocorticoids: Transcriptional and Post-Transcriptional Control
28 Dexamethasone Control of Growth Hormone mRNA Levels in GH3 Pituitary Cells is Cycloheximde-Sensitive and Primarily Posttranscriptional
29 Purification, Subunit Structure, and DNA Binding Properties of the Mouse Oxysterol Receptor
30 Immunocytochemical Localization of the Glucocorticoid Receptor in Steroid-Sensitive and -Resistant Human Leukemic Cells
31 Steroid Mediated Lysis of Lymphoblasts Requires the DNA Binding Region of the Steroid Hormone Receptor
32 Overexpression of Full-Length Human Glucocorticoid Receptor in 'Spodoptera Frugiperda' Cells Using the Baculovirus Expression Vector System
33 Glucocorticoid Effects on Myeloma Cells in Culture: Correlation of Growth Inhibition with Induction of Glucocorticoid Receptor Messenger RNA
34 Increased Glucocorticoid Responsiveness of CD4+ T-Cell Clonal Lines Grown in Serum-Free Media
35 Two Glucocorticoid Binding Sites on the Human Glucocorticoid Receptor
36 Recombinant Human Glucocorticoid Receptor Induces Transcription of Hormone Response Genes 'In Vitro'
37 The Promoter and First, Unstranslated Exon of the Human Glucocorticoid Receptor Gene are GC Rich but Lack Consensus Glucocorticoid Receptor Elements Sites
38 Human Oxysterol-Binding Protein. I. Identification and Characterization in Liver
39 Synergism between Steroid Response and Promoter Elements During Cell-Free Transcription
40 Cortivazol Mediated Induction of Glucocorticoid Receptor Messenger Ribonucleic Acid in Wild-Type and Dexamethasone-Resistant Human Leukemic (CEM) Cells
41 Mapping the Human Glucocorticoid Receptor for Leukemic Cell Death
42 Glucocorticoid Regulation of Lymphoid Cell Growth
43 Glucocorticoid, Interleukin-2, and Prostaglandin Interactions in a Clonal Human Leukemic T-Cell Line
44 Glucocorticoids in Malignant Lymphoid Cells: Gene Regulation and the Minimum Receptor Fragment for Lysis
45 Comment: Single Receptors, Dual Second Messengers
46 Cortivazol Increases Glucocorticoid Receptor Expression and Inhibits Growth of Hamster Pancreatic Cancer (H2T) in Vivo
47 Actions and Interactions of Glucocorticoids and Tranforming Growth Factor β on Two Related Human Myeloma Cell Lines
48 Characterization of the Human Oxysterol Receptor Overexpressed in the Baculovirus System
49 Induction of CD8 Antigen and Suppressor Activity by Glucocorticoids in a CEM Human Leukemic Cell Clone
50 Expression and Purification of the HIV-1 Reverse Transcriptase Using the Baculovirus Expression Vector System
51 Letter to the Editor: Resistance to the HIV-1 Infection by CD4-Positive Lymphoid Cells That Vary in Their Glucocorticoid Receptors and Responses
52 Interactions between Human Immunodeficiency Virus Infection and Hormonal Pathways: Enhancement of Calcium-Induced but Reduction of Glucocorticoid-Induced Cell Death
53 Indentification of the Activation-Labile Gene: A Single Point Mutation in the Human Glucocorticoid Receptor Presents as Two Distinct Receptor Phenotypes
54 Glucocorticoid Receptors in Leukemias, Lymphomas, and Myelomas of Young and Old
55 Extinction of the Prolactin Gene Expression in Somatic Cell Hybrids is Correlated with the Repression of the Pituitary-Specific Trans-Activator GHF-1/Pit-1
56 Suppression of the 'c-myc' is a Critical Step in Glucocorticoid-Induced Human Leukemic Cell Lysis
57 Human Immunodeficiency Virus-1 Reverse Transcriptase Expressed in Baculovirus Infected Cells is Phosphoprotein
58 Oxysterol-Induced Cell Death in Human Leukemic T-Cells Correlates with Oxysterol Binding Protein Occupancy and is Independent of Glucocorticoid-Induced Apoptosis
59 The Role of Glucocorticoids in Cell Growth, Differentiation, and Programmed Cell Death
60 Oxysterol Sensitive and Resistant Lymphoid Cells: Correlation with Regulation of Cellular Nucleic Acid Binding Protein mRNA
61 Heat Shock Protein is Tightly Associated with the Recombinant Human Glucocorticoid Receptor: Glucocorticoid Response Element Complex
62 Leukemic Cell Apoptosis Caused by Constitutively Active Mutant Glucocorticoid Receptor Fragments
63 Efficacy of Prednisone in Refractory Multiple Myeloma and Measurement of Glucocorticoid Receptors
64 Apoptosis and Steroid Hormones
65 Cloning of a Teleost Fish Glucocorticiod Receptor Shows that it Contains a Deoxyribonucleic Acid-Binding Domain Different from that of Mammals
66 Glucocorticoid and Apoptosis of Hematopoietic Cells
67 Glucocorticoid Antagonist RU 486 Reverses Agonist-Induced Apoptosis and C-Myc Repression in Human Leukemic CEM-C7 Cells
68 Successful in Vitro Purging of Leukemic Blasts from Marrow by Cortivazol, a Pyrazolosteroid: A Preclinical Study for Autologous Transplantation in Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma
69 Membrane Transporters of Steroud Hormones
70 Oxysterols and Apoptosis: Evidence for Gene Regulation Outside the Cholesterol Pathway
71 Differential Regulation by Estrogen of c-fos in Hamster Kidney and Estrogen-Induced Kidney Tumor Cells: Receptor Mediation vs. Metabolic Activation
72 Lymphoid Cell Apoptosis by Glucocorticoids: the Roles of C-MYC Down-Regulation and Glucocorticoid Receptor Domains
73 Role of c-jun Induction in the Glucocorticoid-Evoked Apoptotic Pathway in Human Leukemic Lymphoblasts
74 Lymphoid Cell Resistance to Glucocorticoids in HIV Infection
75 Transfected Glucocorticoid Receptor and Certain GR Fragments Evoke Cell Death in Malignant Lymphoid, Not Nyeloid Cell Lines
76 Optimal Ligand Binding by the Recombinant Human Glucocorticoid Receptor and Assembly of the Receptor Complex with Heat Shock Protein 90 Correlate with High Intracellular ATP Levels in 'Spodoptera Frugiperda' Cells
77 Editorial: Molecular Endocrinology, the Early Years: Recollections by the First Editor-In-Chief
78 Elevated Expression of Bcl-2 and Bcl-x by Intestinal Intraepithelial Lymphocytes: Resistance to Apoptosis by Glucocorticoids and Irradiation
79 Characteristics of 25-Hydroxycholesterol-Induced Apoptosis in the Human Leukemic Cell Line CEM
80 Glucocorticoid/Oxyterol-Induced DNA Lysis in Human Leukemic Cells
81 Protein-Protein Interactions are Implied in Glucocorticoid Receptor Mutant 465-Mediated Cell Death
82 Glucocorticoids and Oxysterols in Lymphoid Apoptosis
83 Special Topic: Apopotosis
84 The Many Roles of c-Myc in Apoptosis
85 Steroids, Gene Expression, and Apoptosis: Recollections of Contributions and Controversies
86 Resistance of Human Leukemic CEM-C1 Cells is Overcome by Synergism between Glucocorticoid and Protein Kinase A Pathways: Correlation with c-Myc Suppression
87 Apoptosis Induced by Oxysterol in CEM Cells is Associated with Negative Regulation of c-Myc
88 Trimethylamine N-Oxide-Induced Cooperative Folding of an Intrinsically Unfolded Transcription-Activating Fragment of Human Glucocorticoid Receptor
89 Estrogen-Induced Xicrosatellite DNA Alterations are Associated with Syrian Hamster Kidney Tumorigenesis
90 Activation of Human O6-Methylguanine-DNA Methyltransferase Gene by Glucocorticoid Hormone
91 Structure and Functions of Nuclear Hormone Receptors
92 The Structure of the Nuclear Hormone Receptors
93 Mechanisms of T-cell Apoptosis Induced by Glucocorticoids
94 Normocortisolemic Cushing's Syndrome Initially Presenting with Increased Glucocorticoid Receptor Numbers
95 Glucocorticoids, Oxysterols, and cAMP with Glucocorticoids Each Cause Apoptosis of CEM Cells and Suppress c-myc
96 Homo Sapiens cDNA Clone 44 from HTLV-1 Transformed Lymphocyte Library
97 Interdomain Signaling in a Two-Domain Fragment of the Human Glucocorticoid Receptor
98 HIV-1 Reverse Transciptase is Phosphorylated in Vitro and in a Cellular System
99 Structure-Apoptotic Potency Evaluations of Novel Sterols Using Human Leukemic Cells
100 Glucocorticoid Mediated Transcriptional Repression of c-myc in Apoptotic Human Leukemic CEM Cells
101 Constitutive Expression of Ectopic c-Myc Delays Glucocorticoid-Evoked Apoptosis of Human Leukemic CEM-C7 Cells
102 Hormonal Regulation of Physiological Cell Turnover and Apoptosis
103 Involvement of Caspases in 4-Hydroxy-Alkenal-Induced Apoptosis in Human Leukemic Cells
104 The Delayed Induction of c-junin Apoptotic Human Leukemic Lymphoblasts is Primarily Transcripional
105 Improved Response with Higher Corticosteroid Dose in Children with Acute Lymphoblastic Leukemia
106 Editorial. 2001 Endocrine Reviews 22(1):1
107 The Conformation of the Glucocortoid Receptor AF1/Tau1 Domain Induced by Osmolyte Binds Co-Regulatory Proteins
108 Glucocortoid Receptor Characteristics in Healthy Childrens Leukocytes: Correlation with Gender, Weight, Age and Plasma Cortisol
109 Expression of a DNA Fragment of the Human Glucocorticoid Receptor Gene Kills Brast Cancer Cells
110 Glucocortoids and Polyamine Inhibitors Synergize to Kill Human Leukemic CEM Cells
111 The Pathway of Leukemic Cell Death Caused by Glucocorticoid Receptor Fragment 465
112 Cellulaar Lipid Peroxidation End-Productsinduce Apoptosisin Human Lens Epithelial Cells
113 Oxysterol-Induced Apoptosis in Lymphoid Cells
114 Mutational Analysis of DBD-a Unique Antileukemic Gene Sequence
115 Editorial: The Impact of Genomics and Proteomics on Endocrinology
116 Transactivation Functions of the N-Terminal Domains of Nuclear Hormone Receptors: Protein Folding and Coactivator Interactions
117 Regulation of a Distinctive Set of Genes in Glucocorticoid-Evoked Apoptosis in CEM Human Lymphoid Cells
118 Gene Expression Profile of Human Lymphoid CEM Cells Sensitve and Resistant to Glucocorticoid-Evoked Apoptosis
119 DNA Binding of Nuclear Hormone Receptors Influences their Structure and Function
120 Apoptosis. Glucocorticoid-Induced
121 Gene Networks in Glucocorticoid-Evoked Apoptosis of Leukemia Cells
122 Overview of Cell-Cell and Cell-Matrix Interactions
123 Induced-Helix Structure in AF1 of the Androgen Receptor upon Binding Transcription Factor TFIIF
124 Overview of the Structural Basis for Transcription Regulation by Nuclear Hormone Receptors
125 Pyridinium Cationic Lipids in Gene Delivery: A Stucture Activity Correlation Study
126 Pyridinium Cationic Lipids in Gene Delivery: An in Vitro and Vivo Comparison of Transfection Efficiency Versus a Tetraalklammonium Congener
127 TATA Box Binding Protein Induces Structure in the Recombinant Glucocorticoid Receptor AF1 Domain
128 Identificaton of Genes Leading to Glucocorticoid-Inducedleukemic Cell Death
129 Osmolyte -Induced Folding Enhances Tryptic Enzyme Activity
130 Gene Regulation by the Glucocortoid Receptor: Stucture: Function Relationship
131 p38 Mitogen-Activated Protein Kinase (MAPK) is a Key Mediator in Glucocorticoid-Induced Apoptosis of Lymphoid Cells: Correlation between p38 MAPK Activation and Site Specific Phosphorylation of the Human Glucocorticoid Receptor at Serine 211
132 Activation Function 1 of Glucocorticoid Receptor Binds TATA-Binding Protein in Vitro and in Vivo
133 Molecular Endocrinology-From Birth to 20th Year Anniversary
134 Lipophilic Pyrylium Salts in the Synthesis of Efficient Pyridinium-Based Cationic Lipids, Gemini Surfactants, and Lipophilic Oligomers for Gene Delivery
135 Pathway Interactions between MAPKs, mTOR,PKA and the Glucocorticoid Receptor in Lymphoid Cells
136 In CEM Cells the Autosomal Deafness Gene DFNA5 is Regulated Byglucocorticoids and Forskolin
137 Comparison of Two Structurally Diverse Glucocortoid Receptor Agonists: Cortival Selectively Regulates a Distinct Set of Genes Separate from Dexamethasonein CEM Cells
138 Intrinsic Disorder as a Mecchanismto Optomize Allosteric Coupling in Proteins
139 In CEM Cells the Autosomal Deafness Gene DFNA5 is Regulated Byglucocorticoids and Forskolin
140 Protein Kinase A, not Epac, Supresses Hedgehog Activity and Regulates Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia Cells
141 Effects of Different Osmolytes on the Induced Folding of the N-Terminal Activation Domain (AFI) of the Glucocorticoid Receptor
142 Stepping Stones in the Path of Glucocorticoid-Driven Apoptosis of Lymphoid Cells
143 Protein Kinase A (PKA) Isoform Rllβ Mediates the Synergistics Killing Effect of cAMP and Glucocortoid in Acute Lymphoblastic Leukemia Cells
144 Converting Cell Lines Representing Hematological Malignancies from Glucocorticoid-Resistant to Glucocorticoid-Sensitve: Signaling Pathway Interactions
145 Influence if Flanking Sequence on Signaling between the Activation Function Af1 and DNA Binding Domain of the Glucocorticoid Receptor
146 TMS, a Chemically Modified Herbal Derivative og Resveratrol, Induces Cell Death by Targeting Bax
147 Biomedical Inquiry Spring/Summer 1994
148 Sealy Center for Molecular Science
149 UTMB Quarterly Spring 2003


BOX 3 FOLDERS 150-154/Edward I. Bradbridge Thompson, M.D. Papers (MS 92)/Series 7: Human Biological Chemistry and Genetics Department Files
This series includes American Cancer Society ledger sheets; a list of committees and members; entity narratives; and Medical Research Building floor plans.

Box Folder
3 150 Department of human Biological Chemistry and Genetics
151 American Cancer Society Department Ledger Sheets
152 Committee Members, 1986-1999
153 Entity Narrative, 1999-2004
154 Medical Research Building Floorplans, 5th, and ^th floors


BOX 3 FOLDER 155/Edward I. Bradbridge Thompson, M.D. Papers (MS 92)/Series 8: Miscellaneous
This series includes a Bofors Annual Report.

Box Folder
3 155 Borfors Annual Report, 1982