UT Health Science Center San Antonio

Guide to the Frederic C. Bartter Papers

Descriptive Summary and Abstract

Creator Bartter, Frederic C.
Title: Frederic C. Bartter Papers
Inclusive dates: 1960 - 1990
Abstract: Dr. Frederic C. Bartter was a member of the faculty of the University of Texas Health Science Center at San Antonio from 1978 until his death in 1983. He devoted a major portion of his career to investigating the interrelation between the kidney and various endocrine systems and contributed to aspects of clinical science as diverse as chronobiology, the physiology of taste and smell, and mushroom poisoning. In 1960, Bartter described the syndrome of hyperplasia of the juxtaglomerular complex, which is now commonly termed Bartter's Syndrome or Bartter's Disease. Papers in this collection contain biographical materials and reprints of articles on Bartter's Syndrome.
Identification: MS 18
Extent: 1 bound volume containing reprints of 49 articles and a bibliography
Language: Materials are written in English, French, and German.
Repository University of Texas Health Science Center at San Antonio, UTHSC Libraries, University Archives, San Antonio, TX 78229-3900

Biographical Note

Frederic Crosby Bartter was born in the Philippine Islands on September 10, 1914, the son of George Bartter, an Anglican minister from England, and Frances Buffington, an American teacher. He and his brother, George, were both born in Manila and raised in Baguio, a remote mountain village. His early education was supervised by his father, his mother, and priests at a nearby Catholic monastery. He was sent with his brother to the United States at age thirteen and enrolled at the Lennox School in Lennox, Massachusetts, graduating in 1930. He entered Harvard College and received his Bachelor of Arts degree in 1935, spent a year studying public health, then obtained his M.D. degree from Harvard Medical School in 1940. He interned at Roosevelt Hospital in New York from 1941 to 1942.

Bartter served as an officer in the U.S. Public Health Service during World War II. In 1946 he became a research fellow to Fuller Albright at Massachusetts General Hospital, which was followed by a junior faculty position there. In 1951 he moved to the National Institutes of Health, working in the National Heart and Lung Institute until 1978 while simultaneously serving as faculty at Howard University and Georgetown University. From 1978 – 1983 he served as Professor of Medicine at the University of Texas Health Science Center at San Antonio and Associate Chief of Staff for Research at Audie L. Murphy Memorial Veterans Administration Hospital in San Antonio.

Bartter was best known for his work on the pathophysiology of disease, especially the hormones affecting the kidney. In 1957 he and William B. Schwartz of Tufts University described the syndrome of inappropriate secretion of antidiuretic hormone (ADH). In 1960 he described the syndrome of hyperplasia of the juxtaglomerular complex, now known as Bartter’s Syndrome. He also had a separate interest in mushrooms and mushroom poisoning, being able to identify more than 200 species of mushrooms and giving lectures on mycology and on the symptoms and treatment of mushroom poisoning. He authored over 400 papers and was a member of numerous professional and scientific societies, including the Endocrine Society, the American Society for Clinical Investigation, the Association of American Physicians, the Royal Society of Medicine, the Royal College of Physicians of London, the Peripatetic Club, and the National Academy of Sciences, to which he was elected in 1979.

Bartter died on May 5, 1983 of complications resulting from a cerebral hemorrhage that occurred while he was attending the annual meeting of the National Academy of Sciences. He was married to Jane Lillard and left three children – Frederic C. Bartter, Jr., Thaddeus C. Bartter, and Pamela Reiser.


"Frederic C. Bartter 1914 – 1983: A Biographical Memoir" by Jean D. Wilson and Catherine S. Delea. Biographical Memoirs, Volume 59:2-24. Washington, D.C.: The National Academy Press, 1990.

"Frederic Bartter." Wikipedia.
Viewed October 16, 2014.

Scope and Contents

Papers contain biographical materials from 1969 and 1990 and reprints of articles on Bartter's Syndrome from 1960 – 1983.


Arrangement of Collection

The collection is arranged in one series of published papers in one bound volume.


Access Restrictions

The collection is open for research use. Materials may be viewed in the reading room of the P. I. Nixon Medical Historical Library, located on the 5th floor of the Briscoe Library at the University of Texas Health Science Center at San Antonio.

Use Restrictions

Copyright is retained by the authors of items in these papers, or their descendants, as stipulated by United States copyright law.

Index Terms

Bartter, Frederic C.
Bartter Syndrome
History of Medicine
Document Types

Administrative Information

Preferred Citation

[Identification of item], in the Frederic C. Bartter Papers, MS 18, University Archives, UTHSC Libraries, The University of Texas Health Science Center at San Antonio.


These papers were donated to the University Archives of the University of Texas Health Science Center at San Antonio in 1997 by Mrs. Frederic C. Bartter.

Collection History

These papers were collected by Frederic C. Bartter and donated to the University Archives, the University of Texas Health Science Center at San Antonio in 1997 by Mrs. Frederic C. Bartter.

Processing Information

Finding aid created by: Anne Comeaux, October 2014.

Detailed Description of Collection


Series 1. Reprints

Box-Volume Item
MS 18-1 1 Wilson, Jean D. and Catherine S. Delea. Frederic C. Bartter 1914 – 1983. A Biographical Memoir. Reprinted from Biographical Memoirs, Volume 59:2-25, 1990. Washington, D.C., The National Academy Press.
2 "Frederic C. Bartter."Triangle, Journal Sandoz de Sciences médicales 9:148-150, 1969. Article is in French.
3 Frederic C. Bartter, Sept. 10, 1914 - May 5, 1983. Reprints of Bartter's Syndrome.
Bibliography of reprints of articles on Bartter’s Syndrome.
4 Bartter FC, Pronove P, Gill JR, Jr., and Maccardle RC. Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. American Journal of Medicine 33:811-28, 1962 Dec.
5 Pronove P, MacCardle RC, and Bartter FC. Aldosteronism, hypokalemia, and a unique renal lesion in a five year old boy. Abstract of First Intern Cong of Endocrinology, Copenhagen, 167-168, 1960.
6 Gill JR, Jr. and Bartter FC. Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. Water and Electrolyte Metabolism II (Ed. deGraeff J and Leijnse B), Elsevier Publishing Co., Amsterdam, 119-127, 1964.
7 Bryan GT, Kliman B, Gill JR, Jr., and Bartter FC. Effect of human renin on aldosterone secretion rate in normal man and in patients with the syndrome of hyperaldosteronism, juxtaglomerular hyperplasia and normal blood pressure. Journal of Clinical Endocrinology & Metabolism 24:729-32, 1964 Aug.
8 Bryan GT, MacCardle RC, and Bartter FC. Hyperaldosteronism, hyperplasia of the juxtaglomerular complex, normal blood pressure, and dwarfism: report of a case. Pediatrics 37(1):43-50, 1966 Jan.
9 Bartter FC. So-called Bartter's syndrome. New England Journal of Medicine 281(26):1483-4, 1969 Dec 25.
10 Bartter FC. Bartter’s syndrome: juxtaglomerular hyperplasia, normotension, hypokalemic alkalosis. Journal of the American Medical Association 216:152, 1971.
11 Simopoulos AP, Delea CS, and Bartter FC. Neurodegenerative disorders and hyperaldosteronism. Journal of Pediatrics 79(4):633-41, 1971 Oct.
12 Simopoulos AP and Bartter FC. Growth characteristics and factors influencing growth in Bartter's syndrome. Journal of Pediatrics 81(1):56-65, 1972 Jul.
13 Simopoulos AP, Roth JA, Golde DW and Bartter FC. Subacute necrotizing encephalomyelopathy with vacuolated cells in the bone marrow. Neurology 22(12):1257-67, 1972 Dec.
14 Bartter FC. The syndrome of juxtaglomerular hyperplasia with aldosteronism, hypokalemic alkalosis and normal blood pressure. Birth Defects: Original Article Series 10(4):104-8, 1974.
15 Bartter FC, Delea CS, Kawasaki T, and Gill JR, Jr. The adrenal cortex and the kidney. Kidney International 6(5):272-80, 1974 Nov.
16 Meyer WJ 3rd, Gill JR, Jr, and Bartter FC. Gout as a complication of Bartter's syndrome. A possible role for alkalosis in the decreased clearance of uric acid. Annals of Internal Medicine 83(1):56-9, 1975 Jul.
17 Gill JR, Jr., Frolich JC, Bowden RE, Taylor AA, Keiser HR, Seyberth HW, Oates JA. and Bartter FC. Bartter's syndrome: a disorder characterized by high urinary prostaglandins and a dependence of hyperreninemia on prostaglandin synthesis. American Journal of Medicine 61(1):43-51, 1976 Jul.
18 Bartter FC, Gill JR, Jr., Frolich JC, Bowden RE, et. al. Prostaglandins are overproduced by the kidneys and mediate hyperreninemia in Bartter's syndrome. Transactions of the Association of American Physicians 89:77-91, 1976
19 Bartter FC. Bartter's syndrome. Urologic Clinics of North America. 4(2):253-61, 1977 Jun.
20 Bartter FC, Gill JR, Jr., and Frolich JC. Bartter's syndrome. Advances in Nephrology from the Necker Hospital 7:191-8, 1977.
21 Bartter FC, Gill JR, Jr. and Frolich JC. Le syndrome de Bartter. Adv de Nephrol 7:139-144, 1977. In French.
22 Radfar N, Gill JR, Jr., Bartter FC, Bravo E, Taylor AA and Bowden RE. Hypokalemia, in: Bartter's syndrome and other disorders, produces resistance to vasopressors via prostaglandin overproduction. Proceedings of the Society for Experimental Biology & Medicine 158(3):502-7, 1978 Jul.
23 Vinci JM. Gill JR Jr. Bowden RE. Pisano JJ. Izzo JL Jr. Radfar N. Taylor AA. Zusman RM. Bartter FC. Keiser HR. The kallikrein-kinin system in Bartter's syndrome and its response to prostaglandin synthetase inhibition. Journal of Clinical Investigation 61(6):1671-82, 1978 Jun.
24 Gill JR,Jr. and Bartter FC. Evidence for a prostaglandin-independent defect in chloride reabsorption in the loop of Henle as a proximal cause of Bartter's syndrome. American Journal of Medicine 65(5):766-72, 1978 Nov.
25 Gullner HG. Gill JR Jr. Bartter FC. Chan JC. Dickman PS. A familial disorder with hypokalemic alkalosis, hyperreninemia, aldosteronism, high urinary prostaglandins and normal blood pressure that is not "Bartter's syndrome". Transactions of the Association of American Physicians 92:175-88, 1979.
26 Dusing R, Gill JR, Jr., Bartter FC, et. al. Hypokaliamie und renales Prostaglandin-system beim Menschen. In Verhandlungen der Deutschen Gesellschaft fur innere Medizin, 85 Band, J F Berrgmann, ed. Munchen: Springer-Verlag, 1979. pp 944-947. In German.
27 Gullner HG. Cerletti C. Bartter FC. Smith JB. Gill JR Jr. Prostacyclin overproduction in Bartter's syndrome. Lancet 2(8146):767-9, 1979 Oct 13.
28 Bartter FC. On the pathogenesis of Bartter’s syndrome. Min Elect Metab 3:61-65, 1980.
29 Bartter FC. Role of prostaglandins in potassium-depletion nephropathy. Advances in Prostaglandin & Thromboxane Research 7:1163-70, 1980.
30 Gullner HG. Gill JR Jr. Bartter FC. Lake CR. and Lakatua DJ. Correction of increased sympathoadrenal activity in Bartter's syndrome by inhibition of prostaglandin synthesis. Journal of Clinical Endocrinology & Metabolism 50(5):857-61, 1980 May.
31 Gullner HG, Tiwari JL, Terasaki PI, Gill JR, Jr., and Bartter FC. Genetic linkage between histocompatibility antigens (HLA) and a new syndrome of familial hypokalemia. IRCS Medical Science 8:369-370, 1980.
32 Dusing R, Bartter FC, Gill JR, Jr., et. al. Experimentelle Hypokallamie beim Menschen. Klinische Wochenschrift 58:881-887, 1980. In German.
33 33 Dusing R, Gill JR, Jr., Bartter FC, and Gullner HG. The effect of potassium depletion on urinary prostaglandins in normal men. Adv Prostagl Thromboxane Res 7:1189-1192, 1980.
34 Gullner HG. Smith JB. Cerletti C. Gill JR Jr. and Bartter FC. Correction of increased prostacyclin synthesis in Bartter's syndrome by indomethacin treatment. Prostaglandins & Medicine 4(2):65-72, 1980 Feb
35 Gullner HG. Smith JB. and Bartter FC. The principal metabolites of arachidonic acid are overproduced in Bartter’s syndrome. Adv. Prostagl Thromboxane Res 7:1185-1187, 1980.
36 Simopoulos AP and Bartter FC. The metabolic consequences of chloride deficiency. Nutrition Rev 38:201-205, 1980.
37 Nakada T, Shigematsu H, Bartter FC and Delea CS. Nephropathologic characteristics of a woman with Bartter's syndrome after prolonged treatment with spironolactone. Nephron 26(2):78-84, 1980.
38 Bartter FC. Cyclooxygenase inhibitors and renal function. In: Prostaglandin Synthetase Inhibitors: New Clinical Applications, 267-277, 1980.
39 Bartter FC. Clinical problems of potassium metabolism. Contributions to Nephrology 21:115-122, 1980.
40 Gullner HG, Cerletti C, Bartter FC, et. al. Correction of increased prostacyclin production in Bartter's syndrome by indomethacin. Transactions of the Association of American Physicians 93:130-40, 1980.
41 Dusing R, Bartter FC, Gill JR, Jr., et. al. Effects of moderate short-term potassium depletion in normal humans. The Role of prostaglandins. Prostaglandins 20:971-979, 1980
42 Bartter FC. Bartter's syndrome: a disorder of vascular reactivity. Arthur C. Corcoran Memorial Lecture. Hypertension 3(3 Pt 2):I69-73, 1981 May-Jun.
43 Dusing R, Harrison LC, Bhathena S, Recant L, and Bartter FC. Impairment of insulin secretion during experimental potassium depletion is not corrected by the prostaglandin synthetase inhibitor, indomethacin. Clin Endocrinol 15: 567-572, 1981.
44 Gullner HG, Gill JR, Jr., and Bartter FC. Correction of hypokalemia by magnesium repletion in familial hypokalemic alkalosis with tubulopathy. American Journal of Medicine 578-582, 1981.
45 Bardgett JJ, Stein JH, Bartter FC. Bartter’s syndrome: mechanisms, diagnosis and management. In: Harrison’s Principles of Internal Medicine. Update II (Isselbacher KJ, Adams RD, Braunwald E, editors), New York: McGraw-Hill, 1981 pp 185-195.
46 Bartter FC and Rodriguez JA. Bartter’s syndrome. In: Advances in Internal Medicine and Pediatrics (Ergebnisse der Inneren Medizin und Kinderheilkunde) 50:79-103, 1982. (von P Frick, GA von Harnack, et. al. eds). Heidelberg: Springer-Verlag.
47 Dusing R, Bartter FC, Gill JR, Jr., et. al. Das Bartter Syndrom. Klinische Wochenschrift 61(7):311-9, 1983 Apr 1. In English
48 Gullner HG, Bartter FC, Gill JR, Jr., et. al. A sibship with hypokalemic alkalosis and renal proximal tubulopathy. Archives of Internal Medicine 143:1534-1540, 1983.
49 Bartter FC. Bartter’s syndrome. In: Current Therapy in Endocrinology. (Krieger DT, Bardin CW, eds), Philadelphia: BC Decker Inc., 1983, pp 147-149.
50 Chan JC, Gill JR, Jr., and Bartter FC. Lack of evidence for a role for prostaglandins in the mediation of impaired urinary concentrating ability in Bartter's syndrome. Nephron 35(2):116-119, 1983.