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- Southwest Center for Nursing History
- A Guide to the Southwest Center for Nursing History Archives
- Southwest Texas State Teachers College
- A Guide to the Southwest Texas State Teachers College 50th Anniversary Ceremony Audio Collection, 1951
- Southwestern Ice Manufacturers' Association
- A Guide to the Southwestern Ice Manufacturers' Association Records, 1913-1969
- Southwestern Political and Social Science Association Southwestern Social Science Association
- A Guide to the Southwestern Political and Social Science Association Records, 1919-1962
- Sowell, A. J. (Andrew Jackson), 1848-1921
- A Guide to the A. J. Sowell Papers, undated
- Space Comics Collection
- A Guide to the Space Comics Collection, 1933, 1935
- Spaight, Ashley Wood, 1821-1911
- A Guide to the Ashley Wood Spaight Papers, 1826-1912
- Spanish Material
- A Guide to the Spanish Material from Various Sources Collection, 1600-1921
- Spanish Missions in Texas and California
- A Guide to the Spanish Missions in Texas and California Collection, 1691-1825
- Spears, Ione Petty, 1889-1963
- A Guide to the Ione Spears Items, 1922-1929, undated
- Special Libraries Association, Texas Chapter
- A Guide to the Special Libraries Association, Texas Chapter Archives, 1947-2010
- Special Master, Office of
- A Guide to the Ruiz Case Office of Special Master Records, 1979-1992
- Spector, Warren
- A Guide to the Warren Spector Papers, 1965-2007
- Spell, Jefferson Rea, 1886-1967
- A Guide to the Jefferson Rea Spell Letters, 1941, 1943
- Spell, Lota M. (Lota May), 1885-1972
- A Guide to the Lota May Harrigan Spell Papers, 1861-1967
- Spencer Mitchell, Carol
- A Guide to the Carol Spencer Mitchell Photographic Archive
- Spencer, Donald C
- A Guide to the Donald C. Spencer Papers, 1936-1998
- Spilhaus, Athelstan
- A Guide to the Athelstan Spilhaus Papers, 1912-2003 (bulk 1930-1990)
- Spindletop Oilfield Collection
- A Guide to the Spindletop Oilfield Collection, 1855, 1886-1932
- Splawn, Walter M.W. (Walter Marshall William), 1883-
- A Guide to the Walter Marshall William Splawn Papers, 1913-1927, 1955-1956
- Sponberg, David E
- A Guide to the David E. Sponberg Slide Collection ca. 1968-1977
- Spratt, John S
- A Guide to the Dr. John S. Spratt, Sr. Papers, [ca. 1930]-1983
- Sprinkle, G.K
- A Guide to the Sprinkle (G.K.) Papers, 1973-1991
- Spurr, Stephen H., 1918-1990
- A Guide to the Stephen H. Spurr Papers, 1964-1981
- Squires, Art; Squires, Barbara; Klaw, Marc; Erlanger, Abraham Lincoln
- A Guide to the Art and Barbara Squires Papers, 1901-1996, 2007
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